Orthopedics Research Today is a free monthly online journal that collates and summarizes the latest research about Orthopedics, including details on chronic injuries, muscoskeletal disorders, surgery, reconstruction.

Chemical synthesis of poly(lactic-co-glycolic acid)/hydroxyapatite composites for orthopaedic applications.

Petricca SE, Marra KG, Kumta PN

Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.

Hydroxyapatite-biodegradable polymer composites were synthesized by a colloidal non-aqueous chemical precipitation technique at room temperature. The starting materials used for synthesizing hydroxyapatite (HA, Ca(10)(PO(4))(6)(OH)(2)) were Ca(NO(3))(2) x 4H(2)O and H(3)PO(4), resulting in single phase HA while poly(d,l-lactic-co-glycolic acid) (PLGA) was used as the biodegradable polymer component. The composites were prepared containing 10, 20, and 30 wt.% HA in the presence of the dissolved polymer without evidence of any visible phase separation of the particulates from the PLGA polymer. In addition, the pH changes occurring in the solution during precipitation, the yield of the ceramic due to the chemical reaction, bonding characteristics between the ceramic and the polymer, the microstructure, tensile strength, and thermal stability of the composites have been investigated. Additional in vitro studies include osteoblast-like adhesion assessment on composites utilizing MG63 cells. The results of these studies are described and discussed.

Published 16 May 2006 in Acta Biomater, 2(3): 277-86.
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